This study was carried out to see if there are any peculiar pattern of HLA distribution in patients with thyroid carcinoma. Analysis of tissue antigens were done with Park and Terasaki method on the 25 cases of papillary cancer, 24 cases of
follicular
cancer, and 15 cases of medullary cancer. In order to comparison with benign tumor and healthy person, 21 cases of thyroid adenoma and 30 students were tested.
Compared to the control group, papillary cancer showed high frequencies in HLA-B7, B46, and C6. In follicular cancer, high frequencies occurred in HLA-A33 and HLA-B7. In medullary cancer, distribution was high on HLA-A3 and low an HLA-A24, In
HLA-B
locus, high was shown in B38, B41, and B75 antigens while for HLA-C, C2, and C8 were showed high frequencies.
In follicular adenoma, a benign tumor, HLA-Al, A33 turned out with high frequencies. In HLA-B locus, HLA-B7 and B60 were high in distribution. In HLA-C locus, C6 showed high frequencies. In papillary cancer and follicular adenoma, HLA-B7 and
HLA-C6
were
commonly high.
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